Macrophages display a high degree of plasticity in
disease but their precise role in cancer is not well-understood.Tumour associated
macrophages have been reported to facilitate tumour progression by the release
of key pro-inflammatory chemotatic cytokines and growth
factors. However, the role of resident liver macrophages in the progression of
colorectal liver metastases and the influence of the renin-angiotensin system
(RAS), which can be targeted to inhibit tumour growth, have yet to be defined.
This study aims to determine if the RAS could affect macrophage activation
status and if liver macrophages are altered during growth of liver metastases.
